Night-Time Relax Formula

A daily food supplement to help you find a better sleep. Made with botanicals Lemon Balm, Lavender & Hops. This formula also provides vitamins and minerals to maintain psychological and nervous function, regulate hormone activity and blood glucose levels, in addition to mental performance and stress management which will help you relax and unwind in order to get a great night’s sleep.

The Manuka honey is sourced from our very own Manuka Doctor hives nestled in the luscious green mountains of New Zealand. The honey is freeze dried into powder form and added to our formula which is lovingly made in the UK to the very highest standard. The MGO (methylglyoxal) level in Manuka Honey is derived from DHA (dihydroxyacetone) which is naturally present in the nectar of the Manuka Bush.

Plant-derived capsule shell

Lemon Balm (Melissa officinalis) is a frequently used sleeping remedy for the elderly (lutoMSki, 2000). A 15-day pilot study showed that in a stressed group, Lemon balm leaf extract reduced anxiety and insomnia related to anxiety. In another study it was found that Lemon balm extract significantly reduced the time of falling asleep and extended sleep time. It was also shown that the mixture with lavender extract (Lavandula angustifolia) had a synergistic effect in terms of length of falling asleep and the sleep itself, which may be important in the treatment of insomnia (hajhaSheMi and Safaei, 2015). [1]

A separate study into the extract of stems and flowers of Lavender produced significant sedative effect compared to diazepam. [2]

There is strong evidence that Hops (Humulus lupuls L.) have been used safely for over 30 years to relieve mental stress and to aid sleep and so have been approved by the Committee on Herbal Medicinal Products (HMPC) on their ‘traditional use’. [3]

Vitamin B6 plays an important role in the synthesis of amino acid GABA, tryptophan, and serotonin all of which impact sleep. [4] GABA is produced naturally in the brain. When levels of GABA increase, it suppresses the central nervous system to reduce excitability and, when bound, produces a calming effect that may support a reduction in stress anxiety, and sleeplessness. [5,6] Tryptophan is an amino acid that plays a role in the production of serotonin, the “happy hormone” that helps stabilize our mood. For this reason, vitamin B6 deficiencies have been linked to irritability, emotional disturbances, and disrupted sleep. [7,8]

There is some evidence to support B12 as a regulator of the sleep-wake cycle due to its role in modulating production of melatonin, the sleep hormone, and keeping the circadian rhythms in sync. [9] The vitamin helps increase the production of melatonin during the night-time hours, as well as release it earlier, making it easier to fall and stay asleep. A study published in Neuropsychopharmacology looked at the effects of methyl- and cyanocobalamin on circadian rhythms, well-being, alertness, and concentration in healthy volunteers [10]. They found that methyl B12 (methylcobalamin) was more effective for improving daytime alertness and concentration and shortened and improved sleep patterns in healthy volunteers.

Sources
[1] Katarzyna Swiader et al. The therapeutic properties of Lemon balm (Melissa officinalis): Reviewing novel findings and medical indications. Journal of Applied Botany and Food Quality. Vol 92:327-335. November 2019.
[2] Alnamer, R.; Alaoui, K.; Bouidida, E.H.; Benjouad, A.; Cherrah, Y. Sedative and hypnotic activities of the methanolic and aqueous extracts of Lavandula officinalis from Morocco. Adv. Pharmacol. Sci. 2011, 2012.
[3] EMA. Hop Strobile, Humulus lupulus L. Flos; EMA/HMPC/304459/2016; EMA: Amsterdam, The Netherlands, 2016
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/
[5] https://www.tandfonline.com/doi/abs/10.1080/09637480802558508
[6] https://link.springer.com/article/10.1007/s00726-011-1206-6
[7] https://pubmed.ncbi.nlm.nih.gov/9625217/
[8]https://journals.sagepub.com/doi/abs/10.1177/0031512518770326?journalCode=pmsb&
[9] Okawa M, Mishima K, Nanami T, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13(1):15-23.
[10] Mayer G, Kröger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology. 1996;15(5):456-464.

Take one capsule, one hour before bed. Do not exceed this recommended daily dose. This product should not be used as a substitute for a varied, balanced diet and healthy lifestyle. Please keep out of reach from children.

Discontinue use and consult a doctor if adverse reactions occur. Avoid this product if you have allergies to pollen, bees or bee products. Do not use this product without first consulting with your doctor if you are under medical supervision, on prescribed medication, pregnant, breastfeeding, have asthma or related allergies.

UK Mainland Delivery Rates

Estimated shipping times are from the point of dispatch from our warehouse.

Our Royal Mail option is only available on orders with a weight under 1.5 kg. Order weight is calculated at checkout and the Royal Mail option will be presented at the shipping stage if available.

The Royal Mail option can take 5-7 working days for delivery. Delivery can be tracked.

DPD Pick-up Shop is an option available at the checkout. The customer is responsible for selecting DPD Pickup and choosing their pick-up location. The customer is responsible for then collecting the parcel from this location. The charge for this delivery is £3.50 regardless of order value. If the customer sends a parcel to one of these Pick-up locations using another of our delivery options they will be charged again for delivery to the correct address.

Northern Ireland, Isle of Man, Isle of Wight, Scilly Isles, Scottish Highlands & Islands Delivery Rates

Channel Islands Delivery Rates

Calculation of Shipping Costs

Shipping costs are based on the grand total of your order. If you apply a discount code or loyalty credit your total may change and shipping costs will be recalculated.

Failed Deliveries

If the delivery of your order cannot be completed and it is returned to our warehouse we will contact you to offer two options for your order:
(i) We will re-arrange delivery of your order but you will be required to pay a £3.50 resend fee before the parcel is resent.
(ii) We will refund your order less the £6.50 shipping fee that we are charged by DPD.

Please see clause 8 of the Terms and Conditions of Supply for more information.

Returns

1. If you change your mind and don’t want the Product within 14 days of its delivery to you, your rights to cancel are set out at clause 11 of our Terms and Conditions of Supply. Please note to be eligible for a refund the Product must be unopened, in its original packaging and sealed. We will only be obliged to process any refund due once we have received the Product back from you.

If you are returning your order because you have changed your mind then:
You are responsible for the cost of return postage of the items.

2. If you discover that the Product is faulty or not of satisfactory quality within 30 days of the Product being delivered or us delivering the Product you may also be entitled to a refund or exchange in accordance with clause 11.9 of our Terms and Conditions of Supply.

3. Ensure that if you do want to cancel a contract you follow the cancellation procedure at clause 11 of the Terms and Conditions of Supply. Failure to do so may result in a delay in any refund being processed.

4. We strive to ensure all our Products are of the highest standard. If you do feel there is something wrong with the Product or if you have any questions please feel free to email us on customerservices@manukadoctor.co.uk